C. African Republic leader faces rebel threat

DAMARA, Central African Republic (AP) — More than 30 truckloads of troops from Chad line the two-lane highway just outside of Damara, supporting Central African Republic government forces who want to block a new rebel coalition from reaching the capital.

In a display of force, the turbaned fighters hold their rocket-propelled grenades and other weapons they threaten to use if the rebels seeking to oust President Francois Bozize push this far south.

Gen. Jean Felix Akaga, who heads the regional force known as FOMAC, says a push on Damara, just 75 kilometers (45 miles) north of the capital, would be “a declaration of war” on the 10 Central African states.

“For us, Damara is the red line that the rebels cannot cross,” Akaga said Wednesday. “If they attack Damara, we will attack.”

The United Nations called for talks between the government and rebels and the Security Council scheduled closed consultations on the Central African Republic on Thursday afternoon.

The multinational force brought journalists up to Damara, where they touted the strength of the Chadian troops, who along with forces from Republic of Congo and Gabon are helping to stabilize the area.

The rebels, though, appear to be holding their positions after taking a string of towns including Sibut, which is 70 miles (112 kilometers) further north from Damara.

Back in 2003, troops under Bozize seized the capital amid volleys of machine-gun and mortar fire, and he then dissolved the constitution and parliament. Now a decade later it is Bozize who himself could be ousted from power.

On Wednesday, he announced through a decree read on state radio that he was dismissing his son, Francis, as defense minister. Chief of Staff Guillaume Lapo also was being replaced.

The president already has promised to form a coalition government with rebels and to negotiate without conditions. It’s a sign of how seriously Bozize is threatened by the rebel groups who call themselves Seleka, which means alliance in the Sango language.

Bozize says there’s one point not up for negotiation: he does not intend to leave office before his term ends in 2016.

“We can’t destroy the country. I don’t think that a transition is a good solution for the rebels, for Central African Republic or for the international community,” said Cyriaque Gonda, a spokesman for the political coalition behind Bozize.

But mediators for the government and others note the rebels — an alphabet soup of acronyms in French, UFDR, CPJP, FDPC and CPSK — want Bozize gone. And that’s the only issue the disparate group seems unified on. Seleka is a shaky alliance that lumps together former enemies.

In September 2011, fighting between the CPJP and the UFDR left at least 50 people dead in the town of Bria and more than 700 homes destroyed.

“Even if they show unity in the military action, we know that they are politically very disunited, the only thing that holds them together is the opposition to the current president,” said Roland Marchal, a Paris-based expert on Central African Republic. “If they take control of the capital I think that divisions would appear quickly.”

Gonda, who has negotiated on behalf of the government with the rebels, says some of them couldn’t even accept sitting together as recently as 2008.

Meanwhile, in some parts of the capital, Bangui, a city of 700,000, life continued as normal, while in others the military buildup was evident.

Trucks full of soldiers bounced on rutted roads dotted with shacks where people can charge mobile phones. Police officers stopped vehicles at intersections. Troops from neighboring nations have arrived including about 120 soldiers each from Republic of Congo and Gabon to help stabilize the area between rebel and the government forces.

In the Bimbo neighborhood, traders went about their business, selling everything from leafy greens to meat at roadside stands.

“We don’t support what the rebels are doing,” said banana farmer Narcisse Ngo, as a young boy played nearby with a monkey corpse for sale along with other meat. “They should be at the table negotiating without weapons. We are all Central Africans.”

Bozize, who seized power while the democratically elected president was traveling outside the country, managed to win elections in 2005 but in the years since he has faced multiple low-level rebellions that have shattered security across the northern part of this large but desperately poor country.

He won the 2011 election with more than 64 percent of the vote, though the United States said the voting was “widely viewed as severely flawed.” The U.S. evacuated its diplomats from Bangui last week.

The most prominent among the rebel groups in Seleka is the UFDR, or Union of Democratic Forces for Unity.

Human Rights Watch, which has documented abuses by both government forces and rebel groups operating in the country’s north, says the UFDR rebellion “has its roots in the deep marginalization of northeastern CAR, which is virtually cut off from the rest of the country and is almost completely undeveloped.”

The rebels, though, also have included some of Bozize’s former fighters who helped bring him to power in 2003 but later accused him of failing to properly pay them, among other grievances, Human Rights Watch says.

For the people now caught in the middle, they want life to return to normal.

“Everyone is suffering here — we have nothing to eat,” said Daniel Ngakou, 55, as he watched the Chadian troops patrol his hometown of Damara. “The women are searching in the bush all day for food. We just don’t know what will happen.”

The United Nations called on the government and the rebels Wednesday to focus on dialogue that can avert violence and lead to a peaceful resolution of the conflict and respect for the 2008 Libreville Comprehensive Peace Agreement. That deal was signed by the government and three major rebel groups.

U.N. spokesman Martin Nesirky reiterated the U.N. Security Council’s call last week for all parties to refrain from any acts of violence against civilians, respect human rights and seek a peaceful solution.

“We welcome regional efforts to seek a political solution and reinforce security,” Nesirky told reporters at U.N. headquarters in New York.

While the United Nations has temporarily withdrawn its staff from Central African Republic, Nesirky said the world body remains engaged in efforts to resolve the crisis.

He said U.N. special representative Margaret Vogt “has remained in close dialogue with the key parties in the Central African Republic and the region and has offered support to political negotiations,” he said.

___

Associated Press writer Oleg Cetinic in Paris and Edith M. Lederer at the United Nations contributed to this report.

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The Most and Least Influential Social Media Celebs

While he isn’t currently available for promotional work, businesses would have the most success on social media with President Barack Obama endorsing their goods and services, new research shows.

A study by social marketing platform SocialToaster revealed that Obama is considered the most influential celebrity on social media. Justin Bieber, Lady Gaga, Ashton Kutcher and Anderson Cooper followed the president on the rankings of social influencers.

On the flip side, the research found that former Republican presidential nominee Mitt Romney was the least influential celebrity on social media, finishing just below Madonna, Kanye West and Sean Hannity.

While celebrities might be influential on social media in some aspects, it’s those closest to us who make the largest impact when it comes to the important issues. Nearly all of the social media users surveyed agreed that a social media post from a close friend or family member was most likely to influence them on important subjects, with politicians and athletes the least likely to influence them.

“While it was no surprise that in this election year Barack Obama would be ranked the most influential person in social media, it was surprising to us that Justin Bieber and Lady Gaga would beat Madonna and Kanye West,” said Brian Razzaque, CEO of SocialToaster. “We were also surprised to see that friends had more pull than family when it came to influencing the sharing of social media content.”

Regardless of whom it comes from, there are some posts that will quickly result in an unfollowing, the study discovered. Nearly three-quarters of those surveyed said a racist post would cause them to immediately unfollow someone on social media. Other types of posts that result in a loss of followers include sexism, pornography, repetitive, overly personal posts and those that use poor grammar.

The researcher was based on surveys of 3,000 SocialToaster Super Fans, which consist of social media experts and professionals, many of whom work with some of the nation’s leading brands. The experts range from those who work in the entertainment industry who represent numerous television shows and movies to those who work in professional sports, including the Baltimore Ravens and the Detroit Pistons.

This story was provided by BusinessNewsDaily, a sister site to LiveScience. Follow Chad Brooks on Twitter @cbrooks76 or BusinessNewsDaily @BNDarticles. We’re also on Facebook & Google+.

Copyright 2012 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Flu? Malaria? Disease forecasters look to the sky

NEW YORK (AP) — Only a 10 percent chance of showers today, but a 70 percent chance of flu next month.

That’s the kind of forecasting health scientists are trying to move toward, as they increasingly include weather data in their attempts to predict disease outbreaks.

In one recent study, two scientists reported they could predict — more than seven weeks in advance — when flu season was going to peak in New York City. Theirs was just the latest in a growing wave of computer models that factor in rainfall, temperature or other weather conditions to forecast disease.

Health officials are excited by this kind of work and the idea that it could be used to fine-tune vaccination campaigns or other disease prevention efforts.

At the same time, experts note that outbreaks are influenced as much, or more, by human behavior and other factors as by the weather. Some argue weather-based outbreak predictions still have a long way to go. And when government health officials warned in early December that flu season seemed to be off to an early start, they said there was no evidence it was driven by the weather.

This disease-forecasting concept is not new: Scientists have been working on mathematical models to predict outbreaks for decades and have long factored in the weather. They have known, for example, that temperature and rainfall affect the breeding of mosquitoes that carry malaria, West Nile virus and other dangerous diseases.

Recent improvements in weather-tracking have helped, including satellite technology and more sophisticated computer data processing.

As a result, “in the last five years or so, there’s been quite an improvement and acceleration” in weather-focused disease modeling, said Ira Longini, a University of Florida biostatistician who’s worked on outbreak prediction projects.

Some models have been labeled successes.

In the United States, researchers at Johns Hopkins University and the University of New Mexico tried to predict outbreaks of hantavirus in the late 1990s. They used rain and snow data and other information to study patterns of plant growth that attract rodents. People catch the disease from the droppings of infected rodents.

“We predicted what would happen later that year,” said Gregory Glass, a Johns Hopkins researcher who worked on the project.

More recently, in east Africa, satellites have been used to predict rainfall by measuring sea-surface temperatures and cloud density. That’s been used to generate “risk maps” for Rift Valley fever — a virus that spreads from animals to people and in severe cases can cause blindness or death. Researchers have said the system in some cases has given two to six weeks advance warning.

Last year, other researchers using satellite data in east Africa said they found that a small change in average temperature was a warning sign cholera cases would double within four months.

“We are getting very close to developing a viable forecasting system” against cholera that can help health officials in African countries ramp up emergency vaccinations and other efforts, said a statement by one of the authors, Rita Reyburn of the International Vaccine Institute in Seoul, South Korea.

Some diseases are hard to forecast, such as West Nile virus. Last year, the U.S. suffered one of its worst years since the virus arrived in 1999. There were more than 2,600 serious illnesses and nearly 240 deaths.

Officials said the mild winter, early spring and very hot summer helped spur mosquito breeding and the spread of the virus. But the danger wasn’t spread uniformly. In Texas, the Dallas area was particularly hard-hit, while other places, including some with similar weather patterns and the same type of mosquitoes, were not as affected.

“Why Dallas, and not areas with similar ecological conditions? We don’t really know,” said Roger Nasci of the Centers for Disease Control and Prevention. He is chief of the CDC branch that tracks insect-borne viruses.

Some think flu lends itself to outbreak forecasting — there’s already a predictability to the annual winter flu season. But that’s been tricky, too.

Seasonal flu reports come from doctors’ offices, but those show the disease when it’s already spreading. Some researchers have studied tweets on Twitter and searches on Google, but their work has offered a jump of only a week or two on traditional methods.

In the study of New York City flu cases published last month in the Proceedings of the National Academy of Sciences, the authors said they could forecast, by up to seven weeks, the peak of flu season.

They designed a model based on weather and flu data from past years, 2003-09. In part, their design was based on earlier studies that found flu virus spreads better when the air is dry and turns colder. They made calculations based on humidity readings and on Google Flu Trends, which tracks how many people are searching each day for information on flu-related topics (often because they’re beginning to feel ill).

Using that model, they hope to try real-time predictions as early as next year, said Jeffrey Shaman of Columbia University, who led the work.

“It’s certainly exciting,” said Lyn Finelli, the CDC’s flu surveillance chief. She said the CDC supports Shaman’s work, but agency officials are eager to see follow-up studies showing the model can predict flu trends in places different from New York, like Miami.

Despite the optimism by some, Dr. Edward Ryan, a Harvard University professor of immunology and infectious diseases, is cautious about weather-based prediction models. “I’m not sure any of them are ready for prime time,” he said.

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Sandy Hook students resume classes for first time since school shooting

A bus carrying Sandy Hook students arrives at Chalk Hill School. (Dylan Stableford/Yahoo! News)

MONROE, Conn.—Sandy Hook Elementary School students, many accompanied by their parents, resumed classes at a retrofitted school here on a bitterly cold Thursday morning. Their return comes less than a month after a gunman opened fire at their school in Newtown, killing 20 children and six adults, including principal Dawn Hochsprung, in one of the deadliest school shootings in U.S. history.

Buses began arriving around 8:30 a.m. at Chalk Hill School, seven miles from their former building in Sandy Hook. The snowy roads leading to the school were lined with balloons, green and white ribbons—the school's colors—and signs welcoming the kids back. "Work Hard," one sign affixed to a tree read. "Get Smart. Have Fun," read another.

About a dozen police cruisers were parked at the entrance to the school and officers braved the 13-degree temperatures to direct school traffic. But Monroe Police Lt. Keith White had told reporters on Wednesday that uniformed police presence inside would be toned down to allow a sense of normalcy.

Volunteers spent several weeks moving furniture from Sandy Hook School to the new facility, as school officials tried to completely recreate classrooms in an effort to make students as comfortable as possible—right down, they said, to the way crayons were left on their desks.

"Re-establishing routines following any disaster has been found to promote resiliency while also reducing the negative effects of a tragedy like that which occurred in our school," Newtown Schools Superintendent Janet Robinson wrote in a letter to parents. "We all find safety and predictability in our routines and children are no different."

Robinson also announced on Wednesday that Chalk Hill would be renamed Sandy Hook Elementary.
At a press conference, she said that “the students coming in completes the circle. That's what's missing right now—getting our students back."

She added that grief counselors would be available for students and parents, but that the goal would be "to get back to teaching and learning.

"We will obviously take time out from the academics for any conversations that need to take place, and there will be a lot of support there," she said. "All in all, we want the kids to reconnect with their friends and classroom teachers, and I think that's going to be the healthiest thing."

[Slideshow: Scenes from Newtown, Connecticut]

Parents had been encouraged to attend school with their children on Thursday, though not ride with them on buses.

A sign welcoming Sandy Hook students underneath one pointing to Chalk Hill School. (Dylan Stableford)

"I want to reassure you that we understand many parents may need to be near their children on their first day(s) of school and you will be welcome," interim principal Donna Page had written in her own letter to parents. "That being said, we encourage students to take the bus to school in order to help them return to familiar routines as soon as possible. Parents choosing to join their children may come to school after our 9:07 a.m. opening and will be welcome in the classroom or the auditorium throughout the day."

A note on the school's website warns that parking for parents "may pose some challenges" and that shuttle buses are being provided from an overflow lot at a nearby church.

To "ensure a safe and secure environment," Page continued, "we ask that no more than one adult family member accompany his/her child."

New security systems were installed at Chalk Hill in the wake of the shooting. Earlier this week, Newtown Councilman Steve Vavrek said the school would be "the safest in America"—a phrase that was repeated by Monroe police and school officials on Wednesday, when students and parents were invited to tour the new school.

Other public schools in Newtown reopened within a week of the shootings, but Sandy Hook Elementary has remained closed since Dec. 14, when 20-year-old gunman Adam Lanza shot his way into the school and opened fire before turning a gun on himself. Lanza also killed his mother in their Newtown home before going on the rampage. The school, police officials say, remains a crime scene.

"I want parents and families enduring the loss of their precious children to know their loved ones are foremost in our hearts and minds as we move forward," Page also wrote. "We recognize your needs are paramount in our preparations and planning. Your strength and compassion has been and will continue to be an inspiration to me and countless others as we work to honor the memory of your precious children and our beloved staff."

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“Hunger Games” and “Hobbit” most-anticipated films of 2013: poll

LOS ANGELES (Reuters) – This year will look a lot like 2012 at the box office, with “The Hunger Games” and Hobbits at the top of cinemagoers must-see lists, according to a survey by ticket-seller Fandango released on Thursday.

The second installment in “The Hunger Games” trilogy, “The Hunger Games: Catching Fire,” which is set for a November release, topped the list as 2013′s most-anticipated blockbuster.

The first film in the life-or-death thriller series starring Jennifer Lawrence, raked in some $ 687 million at the worldwide box office in 2012.

“The Hobbit: The Desolation of Smaug,” director Peter Jackson‘s second installment in the “The Hobbit” series of elves and dwarves, ranked second on the survey that polled more than 2,000 moviegoers during the final week of 2012. It is scheduled to hit the big screen in December.

“People love the mega-franchises and that is what gets them most excited,” Dave Karger, Fandango chief correspondent, told Reuters. “The first ‘Hunger Games‘ whetted peoples’ appetites for more. The same can be said for ‘The Hobbit‘ and ‘Iron Man.’”

The superhero thriller “Iron Man 3″ starring Robert Downey Jr. ranked third on the list and is set for a May 3 release.

“Star Trek into Darkness” – the follow-up to 2009′s “Star Trek” science-fiction adventure – and “The Great Gatsby” starring Leonardo DiCaprio rounded out the top five. Both films are set to open in May.

‘JAZZED’ ABOUT FRANCHISES

The heavy dose of franchise films on the list indicates how familiarity can build buzz among moviegoers, Karger said.

“In the case of ‘The Hunger Games,’ many people who loved the movie have read the other books so they’re excited to see it brought to life,” he said. “The same with ‘The Hobbit‘ too.

“Some people say, ‘Where is the originality?’ but the fact of the matter is that these franchises are what people get most jazzed about.”

The survey also asked film fans to vote on the sexiest man and woman on the big screen in 2013, as well as best villain, breakout stars and best apocalyptic films.

Mila Kunis, who stars in upcoming film “Oz: The Great and Powerful,” was voted sexiest actress, while Channing Tatum was voted sexiest man for Paramount’s “G.I. Joe: Retaliation.” Both films are set for March releases.

Ben Kingsley (“Iron Man 3″) was voted most-anticipated villain, and June’s zombie thriller “World War Z” starring Brad Pitt was voted most-anticipated apocalyptic film.

British actress Alice Eve was voted biggest breakout actress for “Star Trek” while fellow Brit Henry Cavill got the nod as biggest breakout actor for playing Superman opposite Russell Crowe and Amy Adams in “Man of Steel,” which will be released in June.

Full results can be viewed at Fandango.com.

(Reporting by Eric Kelsey, editing by Jill Serjeant and Sandra Maler)

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Israeli-Palestinian clashes erupt in West Bank

TAMOUN, West Bank (AP) — An arrest raid by undercover Israeli soldiers disguised as vegetable vendors ignited rare clashes in the northern West Bank on Tuesday, residents said, leaving at 10 Palestinians wounded.

Israeli army raids into Palestinian areas to seize activists and militants are fairly common. The raids are normally coordinated with Palestinian security forces, and suspects are usually apprehended without violence.

The clashes began early Tuesday after Israeli forces disguised as merchants in a vegetable truck arrested one man. Regular army forces then entered the town, prompting youths to hurl rocks to try to prevent more arrests.

Israeli forces fired tear gas, rubber bullets and live ammunition as youths set tires and bins on fire to block the passage of military vehicles. In several hours of clashes, dozens of masked youths hid behind makeshift barriers, hurling rocks and firebombs at soldiers.

Faris Bisharat, a resident of Tamoun, said 10 men were wounded, some by live fire. Bisharat said the wanted men belong to Islamic Jihad, a violent group sworn to Israel’s destruction. It wasn’t clear how many men Israeli forces sought to arrest. There were no immediate details on how seriously the 10 were hurt.

The Israeli military said it arrested a “terrorist affiliated with the Islamic Jihad terror group.” It said two soldiers were injured during the raid.

The fighting, which broke out in several parts of the town of some 8,000 people, were a rare, angry response. It was also unusual for Israeli forces to use live fire toward Palestinian demonstrators. Israel says it uses live fire only in extremely dangerous situations.

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How to Sync All Your Calendars Onto One Smartphone

It’s a simple request: I just want my online calendars to sync with my smartphone… is that too much to ask? It took some initial research and finesse, but I’ve discovered the best ways to get your Yahoo and Google calendars to appear on either an Android or Apple IOS mobile device.

Google Calendar on Android Phone
When you first set up your Android phone, you had to create or enter your Google account info, so the phone already has the login info for your Google Calendar. Now you can go to your phone’s Settings, choose Accounts, click the Google account and then make sure “Sync Calendar” is checked. Then go to the Calendar App on your Android phone and it should be there.

For multiple calendars, hit the Settings button and then Calendars to customize which Google calendars you see.

Yahoo Calendar on Android Phone
Although it seems like it should be easy to add the Yahoo Calendar to your Android, I never got mine to sync. Theoretically, you would open the Android calendar on your phone, hit the Settings option, and Add Account. But depending on the flavor of Android I tried, I either couldn’t add a Yahoo account or when I did, it didn’t sync. It could just be me, but I found a lot of people online with the same issue. So I tried one of the most recommended apps to solve the problem – Smoothsync for Yahoo. It costs just under three dollars, and once you install it, you can sync all your Yahoo calendars into the native Android calendar. Ah, sweet relief.

[Related: New Tricks for New (and Old) Androids]

Yahoo Calendar on iPhone
On your IOS device, hit Settings. If you haven’t added your Yahoo Account yet, do so by going to Mail, Contacts, Calendars. Choose “Add Account.” Once you’ve input your Yahoo login info, the next screen gives you the option to Sync Mail, Contacts, and Calendars. Make sure calendars is on. Hit the Home button, open the IOS calendar. Hit the Calendars button on the top corner and you will see all your calendars listed under Yahoo. If you only have one Yahoo calendar, make sure you check to have it show in your IOS Cal. Also, many people have multiple Yahoo calendars: a family calendar, a work calendar, a soccer team calendar for the kids, and a personal calendar. You can customize which of these Yahoo Calendars show up by checking or unchecking them in this screen.

Google Calendar on iPhone
It’s a little more complicated, but you can also put a Google or Gmail calendar on the iPhone. Here’s how:

If you only have your one personal Google calendar to sync, you do things the same way as with Yahoo: Go to Settings on your IOS device, add your Google account (if you haven’t done so yet) by going to Mail, Contacts, Calendars. Choose “Add Account.”

Once you’ve input your Google login info, the next screen gives you the option to Sync Mail, Contacts, and Calendars. Make sure Calendars is on. Hit the Home button, then open the IOS calendar. Hit the Calendars button on the top corner and you will see your calendar listed under Google. You can track those Google dates in the IOS calendar and multiple Yahoo calendars at the same time.

But if you want multiple Google calendars, you need an app for that. Google does let you do this through their mobile site, but that’s basically just a website without the power of notifications and all the extras you like from your calendars. So I suggest getting the CalenMob app. It’s free with ads or $ 5 ad-free. It syncs all your Google calendars to the app (not the native IOS calendar) and adds in notification options, SMS functions and email alert options. It also syncs simultaneously to your Yahoo calendars.

[Related: True/False: Never Sell Your Old Phone]

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Paparazzo killed on freeway after photographing Justin Bieber’s car

(Reuters) – A celebrity photographer was struck and killed by a car on a Los Angeles highway on Tuesday after snapping photographs of a Ferrari registered to pop star Justin Bieber, police said.

Bieber wasn’t in his car, which had been pulled over by California Highway Patrol officers on Interstate 405 for suspected speeding, Los Angeles Police Department Officer Cleon Joseph said on Wednesday.

Highway patrol officers saw the 29-year-old paparazzo taking photographs of the scene on Tuesday evening and ordered him to return to his car for safety reasons, Joseph said.

The photographer, whose name was not released, refused to leave. After officers repeated their order, he was struck while trying to cross four lanes of traffic, Joseph said.

Charges were unlikely to be filed against the driver who struck the photographer, the officer said.

Bieber was stopped by police for speeding on a Los Angeles freeway last July. He told officers he was being hounded by paparazzi at the time.

Prosecutors charged a celebrity photographer under a California law that criminalizes dangerous driving when taking photos commercially, but a judge later dismissed those counts.

(Reporting by Colleen Jenkins; Editing by Jeffrey Benkoe)

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FDA Approves 39 New Drugs in 2012

Both pharmaceutical companies and officials at the U.S. Food and Drug Administration have been busy — the drug companies compiling statistics from clinical research trials and the FDA going through its vetting process to ensure the safety and efficacy of proposed new medications. The most recently approved medication, Sirturo, was developed for the treatment of multi-drug resistant tuberculosis, MDR-TB, an infection rarely seen in the United States but prevalent in China, Eastern Europe, Russia and India.

FDA 2012 Approval Numbers

In the last 20 years, the greatest number of new approvals occurred in 1996 when 53 new medications were added to the marketplace. In 1997, 39 new drugs met FDA approval. Approvals slowed for some years until 2004 when 36 approvals were awarded by the FDA, then slowed again until the 39 approvals in 2012.

Newest Tuberculosis-Fighting Drug Fast-Tracked by FDA for Approval

Johnson & Johnson’s drug Sirturo, or bedaquiline, intended for the treatment of drug-resistant strains of tuberculosis, received a speedy go-ahead to market, a process used by the FDA when preliminary clinical research demonstrates positive results.

Tuberculosis, caused by bacteria that most often affects the lungs, is rarely seen in the United States but is rampant in other areas of the world. As many as 1.4 million people die worldwide annually from the illness, with approximately 150,000 of those deaths from MDR-TB.

Sirturo, the first new anti-tuberculosis drug to market in more than 40 years, is not without its concerns. Designed to be used in conjunction with the older anti-tuberculosis medications, Sirturo carries a boxed warning on its label that it can interfere with the heart’s electrical system, something that could result in fatal arrhythmia .

Bedaquiline is not intended as a first line of defense against tuberculosis infection, but rather when all other available treatments have been ineffective. Left unabated, the tuberculosis could lead to death and at that point in the illness health care providers would need to weight the possible side effects of a medication that could save the person’s life by clearing the infection.

New Medications Approved by FDA in 2012

The FDA provides a listing of new and generic drugs the agency approved in 2012. Drugs in the listing include Eliquis, a blood thinner for people with atrial fibrillation not related to a heart valve problem; Juxtapid, an anti-cholesterol medication for people with an uncommon genetic disorder affecting LDL cholesterol levels; and Iclusig, another medication that received fast-track approval, for the treatment of two rare types of leukemia. Thirty-six other drugs also received approval.

Bottom Line

The discovery and clinical research that are behind each new drug is often long, arduous and expensive. MedCityNews.com reported that major pharmaceutical companies took a big financial hit in 2012 due to patents expiring on many large money-making medications, with cheaper generic drugs taking up the slack to the tune of $ 21 billion for U.S. drug makers and $ 10 billion for European drug makers.

As difficult as it can be to feel sympathy for the drug companies, the truth is manufacturing and distributing medications is a business. If profits fall too much, it is difficult to fund the discovery and research phases for potential new cures.

Everyone, from infants to baby boomers to centenarians, benefits from the continued science of pharmacy.

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Despite deal, taxes will rise for most

WASHINGTON (AP) — While the tax package that Congress passed New Year's Day will protect 99 percent of Americans from an income tax increase, most of them will still end up paying more federal taxes in 2013.

That's because the legislation did nothing to prevent a temporary reduction in the Social Security payroll tax from expiring. In 2012, that 2-percentage-point cut in the payroll tax was worth about $1,000 to a worker making $50,000 a year.

The Tax Policy Center, a nonpartisan Washington research group, estimates that 77 percent of American households will face higher federal taxes in 2013 under the agreement negotiated between President Barack Obama and Senate Republicans. High-income families will feel the biggest tax increases, but many middle- and low-income families will pay higher taxes too.

Households making between $40,000 and $50,000 will face an average tax increase of $579 in 2013, according to the Tax Policy Center's analysis. Households making between $50,000 and $75,000 will face an average tax increase of $822.

"For most people, it's just the payroll tax," said Roberton Williams, a senior fellow at the Tax Policy Center.

The tax increases could be a lot higher. A huge package of tax cuts first enacted under President George W. Bush was scheduled to expire Tuesday as part of the "fiscal cliff." The Bush-era tax cuts lowered taxes for families at every income level, reduced investment taxes and the estate tax, and enhanced a number of tax credits, including a $1,000-per-child credit.

The package passed Tuesday by the Senate and House extends most the Bush-era tax cuts for individuals making less than $400,000 and married couples making less than $450,000.

Obama said the deal "protects 98 percent of Americans and 97 percent of small business owners from a middle-class tax hike. While neither Democrats nor Republicans got everything they wanted, this agreement is the right thing to do for our country."

The income threshold covers more than 99 percent of all households, exceeding Obama's claim, according to the Tax Policy Center. However, the increase in payroll taxes will hit nearly every wage earner.

Social Security is financed by a 12.4 percent tax on wages up to $113,700, with employers paying half and workers paying the other half. Obama and Congress reduced the share paid by workers from 6.2 percent to 4.2 percent for 2011 and 2012, saving a typical family about $1,000 a year.

Obama pushed hard to enact the payroll tax cut for 2011 and to extend it through 2012. But it was never fully embraced by either party, and this time around, there was general agreement to let it expire.

The new tax package would increase the income tax rate from 35 percent to 39.6 percent on income above $400,000 for individuals and $450,000 for married couples. Investment taxes would increase for people who fall in the new top tax bracket.

High-income families will also pay higher taxes this year as part of Obama's 2010 health care law. As part of that law, a new 3.8 percent tax is being imposed on investment income for individuals making more than $200,000 a year and couples making more than $250,000.

Together, the new tax package and Obama's health care law will produce significant tax increases for many high-income families.

For 2013, households making between $500,000 and $1 million would get an average tax increase of $14,812, according to the Tax Policy Center analysis. Households making more than $1 million would get an average tax increase of $170,341.

"If you're rich, you're almost certain to get a big tax increase," Williams said.

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Follow Stephen Ohlemacher on Twitter: http://twitter.com/stephenatap

Deal moves US away from fiscal cliff - for nowWASHINGTON (AP) -- An emergency deal reached after weeks of rancorous negotiations will keep the U.S. from driving off the so-called fiscal cliff, but higher taxes and continued political bickering in Washington threaten to shake the fragile U.

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