Supreme Court: Both sides in gay marriage debate voice optimism


Both sides of the contentious debate over same-sex marriage in America are expressing optimism over the news Friday that the US Supreme Court has agreed to take up two potential landmark gay rights cases.


The high court announced it would hear arguments in a case testing the constitutionality of California’s Prop. 8 ban on same-sex marriage.


It also said it would hear the case of an elderly New York City woman who claims the federal Defense of Marriage Act (DOMA) violates her right to have her same-sex marriage recognized and respected by the federal government on the same terms as marriages of opposite-sex couples.


Gay marriage laws around the globe


DOMA restricts receipt of federal spousal benefits to marriages comprised of one man and one woman. Same-sex spouses who are legally married in their home states are nonetheless barred from receiving federal benefits under the 1996 law.


The high court action comes a month after voters in three states – Maryland, Washington, and Maine – agreed to join six other states and the District of Columbia in embracing same-sex marriages.


“With our wins at the ballot box last month and the fight for marriage equality reaching our nation’s highest court, we have reached a turning point in this noble struggle,” said Chad Griffin, president of the gay rights group, Human Rights Campaign.


“Today’s announcement gives hope that we will see a landmark Supreme Court ruling for marriage this term,” he said in a statement.


Kate Kendell, of the National Center for Lesbian Rights, sounded similarly optimistic.


“We are confident the Supreme Court will strike down DOMA once and for all next year, and, after four long years, will finally erase the stain of Proposition 8 and restore marriage equality to California couples,” she said.


“The day is now clearly in sight when the federal government, the state of California, and every state will recognize that same-sex couples and their children are entitled to the same respect and recognition as every other family,” Ms. Kendell said.


At the same time, those defending the traditional definition of marriage – as the union of one man and one woman – also viewed the court’s action as a step forward toward legal vindication of their position.


John Eastman, chairman of the National Organization for Marriage, said the court’s decision to take up the Prop. 8 case suggests an intent by the justices to reinstate California’s ban on same-sex marriage.


“We believe it is a strong signal that the court will reverse the lower courts and uphold Proposition 8,” Mr. Eastman said.


“Had the Supreme Court agreed with the lower courts’ decisions invalidating Proposition 8, it could simply have declined to grant … the case,” Eastman said. “It’s a strong signal that the justices are concerned with the rogue rulings that have come out of San Francisco.”


Eastman added that the Prop. 8 appeals court decision was written by Judge Stephen Reinhart. “It’s worth noting that Judge Reinhart is the most overruled judge in America. I think this case will add to his record.”


Others disagreed.


Evan Wolfson, founder and president of Freedom to Marry, said the high court action opens the way for a civil rights breakthrough for same-sex spouses.


“Gay and lesbian couples in California – and indeed all over this country – now look to the Supreme Court to affirm that the Constitution does not permit states to strip something as important as the freedom to marry away from one group of Americans,” he said.


Mr. Wolfson urged the justices to move quickly to affirm the 10 federal court judges who have ruled in recent years that DOMA is unconstitutional.


“When it comes to the whole federal safety net that accompanies marriage – access to Social Security survivorship, health coverage, family leave, fair tax treatment, family immigration, and over 1,000 other protections and responsibilities – couples who are legally married in the states should be treated by the federal government as what they are: married,” Wolfson said.


Others viewed the high court’s task in broader terms.


“Today, the Supreme Court has put itself on the path of deciding the most contentious civil rights issue of our day,” said David Cohen, a law professor at Drexel University in Philadelphia.


“By taking both cases, the court is boldly asserting its role in same-sex marriage,” he said.


Professor Cohen said the justices have a choice to either follow the example of prior courts that have ruled to expand civil rights or those that ruled in ways that contracted civil rights. Given shifting public opinion in support of gay rights and same-sex marriage, the professor says it is unlikely that the court will rule against a broader conception of marriage.


Jim Campbell, a lawyer with the conservative group, Alliance Defending Freedom, stressed that Americans have a right to preserve the traditional definition of marriage. He said the institution forms a “fundamental building block of civilization.”


“Marriage between a man and a woman is a universal good that diverse cultures and faiths have honored throughout the history of Western civilization,” he said. “Marriage expresses the truth that men and women bring distinct, irreplaceable gifts to family life.”


Gay marriage laws around the globe



Related stories


Read this story at csmonitor.com


Become a part of the Monitor community


Read More..

Springsteen, Alabama Shakes top Rolling Stone’s 2012 best music












LOS ANGELES (Reuters) – Veteran rocker Bruce Springsteen and newcomer blues-rock band Alabama Shakes landed the top awards in Rolling Stone magazine‘s annual list of the year’s best music on Friday, which featured many of next year’s leading Grammy nominees.


Springsteen‘s 17th studio album “Wrecking Ball” topped the magazine’s list of best albums, with the magazine calling it “rock’s most pointed response to the Great Recession.”












Springsteen, 63, came in ahead of hip hop artist Frank Ocean‘s debut “Channel Orange” at No. 2 and former White Stripes front man Jack White‘s debut solo effort, “Blunderbuss” at No. 3, in the annual list selected and compiled by Rolling Stone editors.


Springsteen, Ocean and White all landed Grammy nods, which were announced earlier this week.


The rest of the top ten albums included Bob Dylan’s “Tempest,” Green Day’s “¡Uno!,” Neil Young and Crazy Horse’s “Psychedelic Pill,” Kendrick Lamar’s “good kid, m.A.A.d city” and Fiona Apple‘s “The Idler Wheel is Wiser…”


“Hold On” by newcomer blues-rockers Alabama Shakes was named the top song of the year, beating off popular tracks by Ocean, White, Springsteen, Dylan and Kanye West in the top 10.


While both the albums and songs lists were dominated by rock and rap artists both old and new, country-pop star Taylor Swift was a surprising entry at No. 2 on the best songs list with her infectious chart-topping hit song “We Are Never Ever Getting Back Together.”


Rolling Stone described the song, which landed a Grammy nod for record of the year, “a perfect three-minute teen tantrum about country girls getting mad at high-strung indie boys.”


Pop-rockers Passion Pit’s “Take a Walk,” Ocean’s “Thinkin Bout You” and Young and Crazy Horse’s “Ramada Inn” rounded out the top five songs.


Rolling Stone‘s full list of 2012′s 50 best albums can be viewed at http://www.rollingstone.com/music/lists/50-best-albums-of-2012-20121205 and the 50 best songs at http://www.rollingstone.com/music/lists/50-best-songs-of-2012-20121205


(Reporting by Eric Kelsey, Editing by Piya Sinha-Roy and Andrew Hay)


Music News Headlines – Yahoo! News


Read More..

Ghana election, test of democratic reputation












ACCRA, Ghana (AP) — Voters in Ghana were selecting their next president and a 275-seat parliament in elections Friday, solidifying the West African nation‘s reputation as a beacon of democracy in the region.


Some 14 million people are expected to turn out. President John Dramani Mahama, in office for only five months, is running against seven contenders. A former vice president, Mahama became president in July after the unexpected death of former President John Atta Mills. The 54-year-old is also a former minister and parliamentarian and has written an acclaimed biography, “My First Coup d’Etat.”












His main challenger is Nana Akufo-Addo, a former foreign minister and the son of one of Ghana’s previous presidents. The contender lost the 2008 election to Mills by less than 1 percent. Both men are trying to make the case that they will use the nation’s newfound oil wealth to help the poor.


Ghana, a nation of 25 million, is one of the few established democracies in the region as well as the fastest-growing economy. But a deep divide still exists between those benefiting from the country’s oil, cocoa and mineral wealth and those left behind financially.


In an interview on the eve of the vote, Akufo-Addo told The Associated Press that the first thing he will do if elected is begin working on providing free high school education for all. “It’s a matter of great concern to me,” he said, adding that he plans to use the nation’s oil wealth to educate the population, industrialize the economy and create better jobs for Ghanaians.


Policy-oriented and intellectual, Akufo-Addo is favored by the young and urbanized voters. He was educated in England and comes from a privileged family. The ruling party has depicted him as elitist, which Akufo-Addo calls “a little PR construct.”


“The idea that merely because you are born into privilege that automatically means you are against the welfare of the ordinary people, that’s nonsense,” he said.


Ghana had one of the fastest growing economies in the world in 2011. Allegations of corruption against the ruling party are rife.


Akufo-Addo said that if elected, he would not be able to weed out corruption in the government overnight.


“It’s a long fight,” he said. “But we build the institutions that can fight it.”


He said that in 30 years in politics he has never been accused of corruption.


Many analysts believe Mahama and Akufo-Addo are neck-and-neck.


Results are expected to be announced by Sunday, but could be delayed. If no one wins an absolute majority, a second round of voting will be held on December 28.


All candidates have signed a peace pact and have promised to accept the results of Friday’s poll.


Ghana, a nation of 25 million, has previously held five transparent elections in a row. Nearby Mali, which was also considered a model democracy, was plunged into chaos this March following a military coup.


__


Associated Press writer Francis Kokutse contributed to this report from Accra, Ghana.


Africa News Headlines – Yahoo! News


Read More..

Crowdfunding websites clamor for clearer regulation












LONDON (Reuters) – A new breed of internet-based financiers are calling for action to end regulatory uncertainty they say is preventing them from getting money to the small and medium-sized businesses that need it.


The so-called crowdfunding sector raises cash from members of the public to fund lending and investment. Regulators, however, have proved resistant to pleas for adjustments to rules that are tailored to more traditional markets.












“Operators of these platforms find it difficult to launch and flourish because existing EU and UK regulation does not fit the new models,” operators within the sector said in an open letter to EU and UK policymakers on Friday.


The plea coincides with a summit to discuss proposals for regulating a market that has developed in reaction to reduced bank lending to small and medium-sized enterprises because of tougher capital rules and greater regulatory scrutiny.


A host of alternative financing models have cropped up online, many allowing individuals to lend to, or invest in, companies with sums from as little as 10 pounds ($ 16). Massolution, a research and advisory firm specializing in the sector, says that 1.2 billion euros ($ 1.6 billion) was raised globally from crowdfunding last year.


Though some crowdfunding websites have tried to fit their operations within the existing regulatory framework, most remain largely outside it.


Part of the problem in drawing up appropriate regulation is the wide range of activities involved. Some offer debt, some equity, while others seek donations for charity or funding for creative projects in return for some non-financial reward.


With little or no expected returns from the latter, the main regulatory focus would be on equity crowdfunding and peer-to-peer lending.


As well as making sure that individuals are aware of the inherent risk involved with putting money in start-ups, the industry wants to avoid the risk of scams by ensuring that platforms vet businesses adequately.


LOST IN THE CROWD


Britain’s Financial Services Authority (FSA) warned in August that inexperienced investors should be aware of the risks in crowdfunding websites. A few days later United States securities regulators put crowdfunding at the top of their annual investment scams list.


Views differ about how to tackle these risks without stifling an increasingly important source of funding, and the matter is complicated by the varying rules already in place in different countries across Europe.


Measures taken by Seedrs, the only crowdfunding website to have received FSA approval, include requiring investors to pass a test to show that they understand the risks.


“It is hard to come up with a whole securities regulation; sometimes it does have to be a bit incremental and adaptive,” Seedrs founder Jeff Lynn said. “There is no question at all this is going to be a space that will continue to move.”


Some would like the operation of such platforms to be a distinct regulated activity, but others argue for smaller steps, such as a cap on the sums that people can invest or lend.


The British government, keen to improve the flow of finance to small businesses to boost the sluggish economy, has set up a working group to look at all aspects of policy on such sites.


The FSA said that it considers authorization of crowdfunding schemes case by case. The European Commission, meanwhile, is considered as so far having had a largely observational role.


Though the introduction of a separate regulated activity could still be some way off, the co-founder of peer-to-peer site Zopa, Simon Deane-Johns, believes that increased engagement with governments and regulators shows that things are moving in the right direction.


“Over the next year or two it should become progressively easier to set up a platform,” he said, “possibly through a combination of the FSA understanding more readily where things fit within the current regime and balancing that with some self-regulation.”


(Editing by Alexander Smith and David Goodman)


Internet News Headlines – Yahoo! News


Read More..

Jackson’s Hobbit: the journey begins












WELLINGTON (Reuters) – Film maker Peter Jackson wants to scare children with his latest movie – and perhaps even a few grown ups.


The first of the Hobbit movie trilogy – “The Hobbit: An Unexpected Journey” – is about to hit theatres, and Jackson says he’s tried to hold true to its roots as a children’s fantasy story, with scary bits.












“If they’re scared of the trolls great, if they’re scared of the goblins great, they know there are no goblins, they know there are no trolls, it’s a safe kind of danger,” he says.


The film, produced by MGM and Time Warner Inc, is the fourth in the Oscar-winning Jackson’s blockbuster “Lord of the Rings” film franchise, based on the books of author J.R.R. Tolkien.


It follows the journey of hobbit Bilbo Baggins, reluctantly pushed into travelling with 13 dwarves to steal treasure from a dragon and regain their homeland. During his travels, he comes by the ring that he later passes onto kinsman Frodo Baggins, which was at the core of the “Rings” trilogy.


Jackson says he’s worked to keep distance between the Hobbit, published in 1937, and the much darker Lord of the Rings, which came out nearly 20 years later.


“The Lord of the Rings has an apocalyptic sort of heavy themic end-of-the world quality to it, which the Hobbit doesn’t, which is one of the delights of it,” he said.


POMPOUS AND SMALL MINDED


The pointy eared, hairy footed hobbit Bilbo is played by British actor Martin Freeman, who says he’s tried to make Bilbo his own creation, a character audiences can root for despite his initial pomposity and small mindedness.


“You have to be able to follow him for the duration of the film, but I wanted him to be open and changeable and ready to be surprised,” Freeman said.


A key scene is an encounter in a cave between Bilbo and the creature Gollum, reprised in full computer generated splendor by Andy Serkis with the distinctive throaty whisper.


“It was a very rich experience,” he said, adding that playing Gollum again was “an absolute thrill”.


Such is the affection for the creature, who calls the magic ring “Precious”, that a 13 meter (42 feet) sculpture of Gollum hangs in the airport terminal at Wellington, which regards itself as the spiritual home of the Tolkien films and terms itself the “Middle of Middle Earth”.


Returning actors from the Rings trilogy, many of whom have only passing mention in the book, were no less enthusiastic. Ian McKellen returns for a leading role as the wispy-haired, grey bearded wizard, Gandalf, while Cate Blanchett is the elven queen Galadriel and Elijah Wood appears as Frodo Baggins.


“You couldn’t not come back, you had to come back,” says Hugo Weaving, the leader of the elves, Elrond.


HOBBIT – A FRAUGHT JOURNEY


The Hobbit film journey has not been without its setbacks.


Metro-Goldwyn-Mayer, owners of the film rights to the Tolkien books, had financial woes, prompting original director Guillermo del Toro to pull out and Jackson, already script writer and executive producer, to step in.


A major labor dispute prompted threats to move production out of New Zealand, and was solved by changing labor laws, while Jackson suffered a perforated ulcer and underwent surgery, delaying the film still further.


Though only two films were planned originally, Jackson has tapped Tolkien’s appendices to the Rings to make it into three.


Audiences are also getting more visual bangs for their buck, with the movies filmed in 3D and at 48 frames per second (fps), double the industry standard.


This delivers clearer pictures, but opinion is divided, with some critics calling it cartoon-like and jarring.


Jackson says he wants to drag the iPad generation back into theatres and the romance, excitement and mystery they offer.


“It’s more realistic, it’s more immersive. I almost feel a responsibility as a film maker to try to do my part at encouraging people to come to the movies, to watch the film in a cinema,” he said.


The second film “The Hobbit: The Desolation of Smaug” will be released in December next year, with the third “The Hobbit: There and Back Again” is due in mid-July 2014.


(Reporting by Gyles Beckford, editing by Elaine Lies)


Movies News Headlines – Yahoo! News


Read More..

House panel seeks compounder group papers in meningitis probe












WASHINGTON (Reuters) – A U.S. congressional committee that oversees drug safety issues has asked a compounding pharmacists’ industry association to provide documents on the group’s role in helping pharmacies in their interactions with federal and state authorities.


The request to the International Academy of Compounding Pharmacists came as the House Energy and Commerce Committee continues an investigation into a deadly meningitis outbreak caused by contaminated compounded drugs.












In a letter released on Friday, 10 lawmakers cited a media report that the group “tutored pharmacists on how to sidestep” U.S. Food and Drug Administration requests for samples that would help the agency assess the quality of compounded drugs.


“Allegations that your association may have encouraged compounding pharmacists to attempt to impede the FDA from evaluating the efficacy and safety of their products, if true, raise serious concerns,” the lawmakers said.


The meningitis outbreak, linked to steroid injections from the Massachusetts-based New England Compounding Center, has sickened 541 people, 36 of whom have died, according to the U.S. Centers for Disease Control and Prevention.


(Reporting by Ros Krasny; Editing by Lisa Von Ahn)


Medications/Drugs News Headlines – Yahoo! News


Read More..

Jobless rate hits four-year low, but economists skeptical



As much as his fans scream and yell when he walks on water or levitates, most people have a pretty good idea that magician/illusionist Criss Angel is somehow tricking them and not actually defying the laws of physics.


In much the same why, when this morning's surprisingly strong jobs data came out, professional investors and economists alike knew immediately that something was up. In a month when one of the nation's most disruptive storms in recent history occurred, for the Bureau of Labor Statistics to report that Hurricane Sandy did not have an impact and the unemployment rate fell to a four-year low of 7.7% and 146,000 new jobs were created, that defies the laws of reason.


"It's a little hard to believe quite honestly," says Dan North, chief economist at Euler Hermes, in the attached video. "If there's any report that deserved caveats and conditions it's this one."


And he's not alone. Peter Kenny from Knight Capital calls the report a ''head scratcher'' in a note to clients today, saying he never looks a gift horse in the mouth, but just can't get comfortable with the numbers. And Andrew Wilkinson, chief economic strategist at Miller, Tabak & Co., who correctly called for a much stronger than expected number yesterday, is already expecting the 20,000 reduction in construction jobs to be short-lived, reminding clients that "we know what follows any disaster."


Related: Resist Urge to Panic on November Jobs Report Says Wilkinson


It's not like the markets weren't ready for a wild pitch, so to speak, of a jobs report. The Wall Street Journal went as far as calling it "the least important jobs report in five years" given the diffused post-election environment and the fact the Fed meets next week.


The reaction in financial markets so far has been modest, as investors are seeing right through the headline number and seized upon the fact that the labor force fell by 350,000 last month, while the participation rate also dipped to 63.6%.


"You saw the unemployment go down this month sharply, but probably for the wrong reason," North says, adding that the report is positive but still "way short of what we need to have for good growth."


With the jobs report now behind us, we begin to get set for the Fed's last meeting of the year, next Tuesday and Wednesday, with comparably low expectations, as economists like North, and presumably those that sit alongside Ben Bernanke at the central bank too, did not see this report as a game changer in any way.


What that means is that we can, as they say in the TV business, return to our regularly scheduled programming which means our singular focus on fiscal cliff resolutions can resume.



Read More..

Ghana election, test of democratic reputation












ACCRA, Ghana (AP) — Voters in Ghana were selecting their next president and a 275-seat parliament in elections Friday, solidifying the West African nation‘s reputation as a beacon of democracy in the region.


Some 14 million people are expected to turn out. President John Dramani Mahama, in office for only five months, is running against seven contenders. A former vice president, Mahama became president in July after the unexpected death of former President John Atta Mills. The 54-year-old is also a former minister and parliamentarian and has written an acclaimed biography, “My First Coup d’Etat.”












His main challenger is Nana Akufo-Addo, a former foreign minister and the son of one of Ghana’s previous presidents. The contender lost the 2008 election to Mills by less than 1 percent. Both men are trying to make the case that they will use the nation’s newfound oil wealth to help the poor.


Ghana, a nation of 25 million, is one of the few established democracies in the region as well as the fastest-growing economy. But a deep divide still exists between those benefiting from the country’s oil, cocoa and mineral wealth and those left behind financially.


In an interview on the eve of the vote, Akufo-Addo told The Associated Press that the first thing he will do if elected is begin working on providing free high school education for all. “It’s a matter of great concern to me,” he said, adding that he plans to use the nation’s oil wealth to educate the population, industrialize the economy and create better jobs for Ghanaians.


Policy-oriented and intellectual, Akufo-Addo is favored by the young and urbanized voters. He was educated in England and comes from a privileged family. The ruling party has depicted him as elitist, which Akufo-Addo calls “a little PR construct.”


“The idea that merely because you are born into privilege that automatically means you are against the welfare of the ordinary people, that’s nonsense,” he said.


Ghana had one of the fastest growing economies in the world in 2011. Allegations of corruption against the ruling party are rife.


Akufo-Addo said that if elected, he would not be able to weed out corruption in the government overnight.


“It’s a long fight,” he said. “But we build the institutions that can fight it.”


He said that in 30 years in politics he has never been accused of corruption.


Many analysts believe Mahama and Akufo-Addo are neck-and-neck.


Results are expected to be announced by Sunday, but could be delayed. If no one wins an absolute majority, a second round of voting will be held on December 28.


All candidates have signed a peace pact and have promised to accept the results of Friday’s poll.


Ghana, a nation of 25 million, has previously held five transparent elections in a row. Nearby Mali, which was also considered a model democracy, was plunged into chaos this March following a military coup.


__


Associated Press writer Francis Kokutse contributed to this report from Accra, Ghana.


Africa News Headlines – Yahoo! News


Read More..

Firm says first BlackBerry 10 phone to debut in March, QWERTY phone won’t launch until June












Research In Motion (RIMM) is gearing up for a series of make-or-break releases that could be considered the most important device launches in the company’s history. Everything is riding on the success of the RIM’s BlackBerry 10 platform, which will be unveiled in its finished state on January 30th next year. RIM CEO Thorsten Heins is on record confirming that BlackBerry 10 will launch in the first quarter and company COO Kristian Tear previously stated new BlackBerry devices will be available “not too long after” the platform is unveiled late next month, but exact timing is still a mystery. According to Boston-based brokerage firm Detwiler Fenton, however, RIM’s first two BlackBerry 10 handsets won’t launch until March and June, respectively.


“RIM’s stock has been on a tear recently thanks to a number of upgrades and optimism surrounding its upcoming BB10 platform,” Detwiler analysts wrote in a note to clients picked up by Forbes. “However, as we dig a little deeper, there appears to be a few issues that could set up for some disappointing numbers in the 2013 first half.”












The firm goes on state that AT&T (T) and T-Mobile will launch the first BlackBerry 10 smartphone some time in March, while Verizon Wireless (VZ) and Sprint (S) are targeting May launches. Detwiler also states that the second BlackBerry 10 smartphone, which will feature a touchscreen and a full QWERTY keyboard, might not launch until June.


“Therefore, it is possible RIMM’s February quarter may only see a very small number of BB10 sales with the May quarter also coming in light due to limited QWERTY keyboard shipments and limited shipments to Sprint and Verizon,” the firm continued. “It’s our opinion RIM will ship approximately 400,000 BB10 units in the February quarter and 2.2 million to 2.5 million units in the May quarter. While this is clearly a North American / developed market view, we think this is the right way to look at the 2013 first half because the initial BB10 handsets are higher end and not targeted for emerging markets.”


When asked to comment on the Detwiler note, RIM spokesman Nick Manning reiterated the company’s earlier position. ”Details of the commercial availability for BlackBerry 10 will be announced at the global launch events on January 30,” Manning said in a comment provided to BGR via email. “Our executives have made it clear that the touch screen device will be available shortly after launch with the physical keyboard version to follow shortly after that.”


BGR’s own sources were not able to provide details regarding the exact timing of RIM’s upcoming launches, however we are hearing from reliable sources that RIM’s QWERTY-equipped BlackBerry 10 smartphone will launch well ahead of the June timeframe mentioned by Detwiler.


Get more from BGR.com: Follow us on Twitter, Facebook


Wireless News Headlines – Yahoo! News


Read More..

Aspirin may help older colon cancer patients live longer












NEW YORK (Reuters Health) – Older adults with colon cancer who were prescribed a daily aspirin were less likely to die than those who weren’t, according to a new study.


While the results need to be confirmed with more rigorous studies, they add to the evidence linking aspirin use to longer survival for cancer patients. Studies have also suggested the inexpensive drug can prevent some types of the disease from occurring in the first place.












Medical guidelines currently endorse the use of low-dose aspirin to prevent heart disease, but not to fight or prevent cancer.


The new study, published in the Journal of the American Geriatrics Society, included more than 500 colon-cancer patients in the Netherlands aged 70 and older. More than 100 were prescribed daily low-dose “baby” aspirin for heart protection after their cancer diagnosis.


Between 1998 and 2007, the death rate for those prescribed aspirin was about half that of the non-aspirin users. The effect was biggest in people with more advanced cancer and in those who received no chemotherapy.


Anything that might improve survival in elderly adults with colon cancer would be welcome, since there is no consensus on whether to use chemotherapy in those patients, according to the study.


Previous studies have also associated aspirin use with increased survival. Research published in October in the New England Journal of Medicine suggested that aspirin therapy could extend survival for colon cancer patients whose tumors had a specific genetic mutation.


Still, more scientifically rigorous randomized controlled trials will be needed to confirm the findings of studies that are based on observation after the fact, and therefore less definitive about what actually causes the effect seen.


“We’re pretty sure this is a real effect, but we’re not sure of the magnitude,” said Dr. Gerrit Jan Liefers of Leiden University Medical Center in the Netherlands, an author of the new study. He said he didn’t expect randomized trials would show such a large survival advantage. Liefers is working to develop such a trial in the Netherlands.


One limitation of the study is that it looked at aspirin prescriptions, not actual use of the drug. (Low-dose aspirin for heart-disease protection isn’t available over the counter in the Netherlands.) It’s possible that heart benefits from aspirin might have helped the patients live longer, but the study authors said that alone couldn’t account for the big difference in death rates. Also, there might be differences between the groups unaccounted for by researchers that led to the improved survival among the aspirin users.


Liefers said it’s not completely clear how aspirin might combat colon cancer. One likely route: blocking the enzyme cyclooxygenase-2, or COX-2, which is involved in inflammation and is expressed in about 70 percent of colon tumors.


Boris Pasche, director of the hematology and oncology division at the University of Alabama at Birmingham, said it would be helpful to figure out who would benefit from and who could skip daily aspirin.


“It’s a fairly benign drug, but it has side effects,” including bleeding in the gastrointestinal tract and the brain, Pasche said.


He said patients should discuss with their physicians whether it makes sense to take aspirin at this point. “This supports the concept, but we need a prospective randomized trial,” he said.


SOURCE: http://bit.ly/TFEnSF Journal of the American Geriatrics Society, online November 23, 2012.


Diseases/Conditions News Headlines – Yahoo! News


Read More..